InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp326

Summary

InnateDB Protein

IDBP-186171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp326

Protein Name

zinc finger protein 326

Synonyms

5730470H14Rik; ZAN75; Znf326;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031227

InnateDB Gene

IDBG-186169 (Zfp326)

Protein Structure

UniProt Annotation

Function

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). May also play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro. {ECO:0000250, ECO:0000269PubMed:10798446}.

Subcellular Localization

Nucleus matrix {ECO:0000269PubMed:10798446, ECO:0000269PubMed:9809746}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in adult tissues. Highly expressed in neuronal tissues such as brain and neural tube. {ECO:0000269PubMed:10798446, ECO:0000269PubMed:9809746}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000993	RNA polymerase II core binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0032784	regulation of DNA-templated transcription, elongation
GO:0045893	positive regulation of transcription, DNA-templated