InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinb2

Summary

InnateDB Protein

IDBP-186365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinb2

Protein Name

serine (or cysteine) peptidase inhibitor, clade B, member 2

Synonyms

ovalbumin; PAI-2; Planh2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009356

InnateDB Gene

IDBG-186363 (Serpinb2)

Protein Structure

UniProt Annotation

Function

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1. Not required for normal murine development or survival.

Subcellular Localization

Cytoplasm. Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0042060	wound healing
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)