Version 5.4
Mus musculus Protein: Fgd6
Summary
InnateDB Protein IDBP-186439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgd6
Protein Name FYVE, RhoGEF and PH domain containing 6
Synonyms AA123052; Etohd4; ZFYVE24;
Species Mus musculus
Ensembl Protein ENSMUSP00000020208
InnateDB Gene IDBG-186437 (Fgd6)
Protein Structure
UniProt Annotation
Function May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:1261419
InterPro IPR000219 Dbl homology (DH) domain
IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR017455 Zinc finger, FYVE-related
PFAM PF00621
PF01363
PF00169
PRINTS
PIRSF
SMART SM00325
SM00064
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q69ZL1
PhosphoSite PhosphoSite-Q69ZL1
TrEMBL
UniProt Splice Variant
Entrez Gene 13998
UniGene Mm.420803
RefSeq NP_444302
MGI ID 1WGQ
MGI Symbol Fgd6
OMIM
CCDS CCDS48674
HPRD
IMGT
EMBL AK016940 AK044341 AK173157 BC026860
GenPept AAH26860 BAB30510 BAC31876 BAD32435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca