InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtf1

Summary

InnateDB Protein

IDBP-186886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtf1

Protein Name

metal response element binding transcription factor 1

Synonyms

MTF-1; Thyls;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030723

InnateDB Gene

IDBG-186884 (Mtf1)

Protein Structure

UniProt Annotation

Function

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11005378}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046686	response to cadmium ion