InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glmn

Summary

InnateDB Protein

IDBP-187049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glmn

Protein Name

glomulin, FKBP associated protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077168

InnateDB Gene

IDBG-187045 (Glmn)

Protein Structure

UniProt Annotation

Function

Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. May stimulate the p70S6K pathway. May inhibit cell proliferation and increase IL2 production (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005171	hepatocyte growth factor receptor binding
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0055105	ubiquitin-protein transferase inhibitor activity

Biological Process

GO:0001570	vasculogenesis
GO:0001843	neural tube closure
GO:0031397	negative regulation of protein ubiquitination
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0040029	regulation of gene expression, epigenetic
GO:0042130	negative regulation of T cell proliferation
GO:0042327	positive regulation of phosphorylation
GO:0042692	muscle cell differentiation
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0050715	positive regulation of cytokine secretion
GO:0072359	circulatory system development

Cellular Component

GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031462	Cul2-RING ubiquitin ligase complex
GO:0031463	Cul3-RING ubiquitin ligase complex
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex