InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sco1

Summary

InnateDB Protein

IDBP-187057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sco1

Protein Name

SCO cytochrome oxidase deficient homolog 1 (yeast)

Synonyms

2610001C07Rik; D11Bwg1310e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090673

InnateDB Gene

IDBG-187055 (Sco1)

Protein Structure

UniProt Annotation

Function

Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005507	copper ion binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006825	copper ion transport
GO:0006878	cellular copper ion homeostasis
GO:0008150	biological_process
GO:0008535	respiratory chain complex IV assembly
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0030016	myofibril

Protein Structure and Domains

PDB ID

MGI:106362

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR003782 Copper chaperone SCO1/SenC
IPR012336 Thioredoxin-like fold
IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2

PFAM

PF00578
PF02630
PF13098
PF13192
PF13462
PF13905

PRINTS

PIRSF

PIRSF037736

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5SUC9