InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLRX5

Summary

InnateDB Protein

IDBP-18711.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRX5

Protein Name

glutaredoxin 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328570

InnateDB Gene

IDBG-18709 (GLRX5)

Protein Structure

UniProt Annotation

Function

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Anemia, sideroblastic, pyridoxine-refractory, autosomal recessive (PRARSA) [MIM:205950]: A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. {ECO:0000269PubMed:17485548}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0046872	metal ion binding
GO:0051537	2 iron, 2 sulfur cluster binding