InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: E2f4

Summary

InnateDB Protein

IDBP-187181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2f4

Protein Name

E2F transcription factor 4

Synonyms

2010111M04Rik; AI427446;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015003

InnateDB Gene

IDBG-187179 (E2f4)

Protein Structure

UniProt Annotation

Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances, can also bind RB1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0002064	epithelial cell development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006884	cell volume homeostasis
GO:0008015	blood circulation
GO:0008361	regulation of cell size
GO:0009887	organ morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042384	cilium assembly
GO:0051726	regulation of cell cycle