InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nudt4

Summary

InnateDB Protein

IDBP-187190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt4

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 4

Synonyms

4933436C10Rik; DIPP2; DIPP2alpha; DIPP2beta; HDCMB47P;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020217

InnateDB Gene

IDBG-187188 (Nudt4)

Protein Structure

UniProt Annotation

Function

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity
GO:0016787	hydrolase activity
GO:0030515	snoRNA binding
GO:0046872	metal ion binding
GO:0052840	inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052843	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052844	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052845	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052846	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052847	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052848	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity