InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krt8

Summary

InnateDB Protein

IDBP-187354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krt8

Protein Name

keratin 8

Synonyms

AA960620; AL022697; AU019895; Card2; EndoA; K8; Krt-2.8; Krt2-8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023952

InnateDB Gene

IDBG-187352 (Krt8)

Protein Structure

UniProt Annotation

Function

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in abundance in the epithelia of colon, bladder, ileum, and stomach, with lower expression observed in earskin (at protein level). Also expressed in pancreas, liver, dudenum and jejunum. {ECO:0000269PubMed:12857878}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0097110	scaffold protein binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0007275	multicellular organismal development
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0045214	sarcomere organization
GO:0046417	chorismate metabolic process
GO:0051599	response to hydrostatic pressure
GO:0051707	response to other organism
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097284	hepatocyte apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0005911	cell-cell junction
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016363	nuclear matrix
GO:0030018	Z disc
GO:0042383	sarcolemma
GO:0043034	costamere
GO:0045095	keratin filament
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery