Version 5.4
Mus musculus Protein: Lpcat3
Summary
InnateDB Protein IDBP-187389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lpcat3
Protein Name lysophosphatidylcholine acyltransferase 3
Synonyms C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat; Mboat5; Moact5; Oact5; PTG;
Species Mus musculus
Ensembl Protein ENSMUSP00000004381
InnateDB Gene IDBG-187387 (Lpcat3)
Protein Structure
UniProt Annotation
Function Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), and the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl- CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18287005}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18287005}; Multi-pass membrane protein {ECO:0000269PubMed:18287005}.
Disease Associations
Tissue Specificity Detected ubiquitously, with high expression levels in testis. {ECO:0000269PubMed:18287005}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
Biological Process
GO:0008654 phospholipid biosynthetic process
GO:0097006 regulation of plasma lipoprotein particle levels
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1315211
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91V01
PhosphoSite PhosphoSite-Q91V01
TrEMBL
UniProt Splice Variant
Entrez Gene 14792
UniGene Mm.273915
RefSeq NP_660112
MGI ID
MGI Symbol Lpcat3
OMIM
CCDS CCDS20523
HPRD
IMGT
EMBL AB294194 AC002397 AK083687 AY028317 BC006753 CH466523
GenPept AAC36007 AAH06753 AAK20915 BAC38993 BAG12120 EDK99746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca