InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmem30a

Summary

InnateDB Protein

IDBP-187631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmem30a

Protein Name

transmembrane protein 30A

Synonyms

2010200I23Rik; AW540225; Cdc50a; D9Wsu20e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034878

InnateDB Gene

IDBG-187629 (Tmem30a)

Protein Structure

UniProt Annotation

Function

Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet- activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269PubMed:22641037, ECO:0000269PubMed:23269685}.

Subcellular Localization

Membrane {ECO:0000269PubMed:22253360}; Multi-pass membrane protein {ECO:0000269PubMed:22253360}. Cell membrane {ECO:0000250}. Golgi apparatus {ECO:0000269PubMed:22253360}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269PubMed:22253360}. Apical cell membrane {ECO:0000269PubMed:22253360}.

Disease Associations

Tissue Specificity

Expressed in photoreceptor cells; detected in retina outer segment (at protein level). Detetced in hepatocytes liver sinusoidal endothelial cells and kidney brush border of the proximal tubules (at protrein level). {ECO:0000269PubMed:22253360, ECO:0000269PubMed:22307598, ECO:0000269PubMed:24413176}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006855	drug transmembrane transport
GO:0010976	positive regulation of neuron projection development
GO:0036010	protein localization to endosome
GO:0045332	phospholipid translocation
GO:0070863	positive regulation of protein exit from endoplasmic reticulum