InnateDB Protein
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IDBP-187677.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Csrp3
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Protein Name
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cysteine and glycine-rich protein 3
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Synonyms
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CRP3; MLP; MMLP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000032658
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InnateDB Gene
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IDBG-187675 (Csrp3)
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Protein Structure
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Function |
Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. {ECO:0000269PubMed:15665106, ECO:0000269PubMed:9039266}.
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Subcellular Localization |
Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:18258855}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:18258855}. Note=Mainly cytoplasmic. In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (via C-terminus). {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1330824
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
P50462
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PhosphoSite |
PhosphoSite-P50462
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TrEMBL |
Q545C7
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UniProt Splice Variant |
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Entrez Gene |
13009
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UniGene |
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RefSeq |
NP_001185770
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MGI ID |
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MGI Symbol |
Csrp3
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OMIM |
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CCDS |
CCDS21305
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HPRD |
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IMGT |
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EMBL |
AK003120
AK011624
BC061131
CH466603
D88791
Z49883
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GenPept |
AAH61131
BAA13721
BAB22580
BAB27741
CAA90039
EDL22967
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