Version 5.4
Mus musculus Protein: Poc1b
Summary
InnateDB Protein IDBP-187731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Poc1b
Protein Name POC1 centriolar protein homolog B (Chlamydomonas)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020113
InnateDB Gene IDBG-187729 (Poc1b)
Protein Structure
UniProt Annotation
Function Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Component of both mother and daughter centrioles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008283 cell proliferation
GO:0042384 cilium assembly
Cellular Component
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005814 centriole
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID MGI:1918511
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BHD1
PhosphoSite PhosphoSite-Q8BHD1
TrEMBL Q9D3W6
UniProt Splice Variant
Entrez Gene 382406
UniGene Mm.462507
RefSeq NP_082016
MGI ID
MGI Symbol Poc1b
OMIM
CCDS CCDS36045
HPRD
IMGT
EMBL AC153504 AK016991 AK030180 AK045302 AK050233 AK090075
GenPept BAB30542 BAC26826 BAC32302 BAC34138 BAC41080

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca