InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htatip2

Summary

InnateDB Protein

IDBP-187938.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htatip2

Protein Name

HIV-1 tat interactive protein 2, homolog (human)

Synonyms

AW111545; Cc3; Tip30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000082374

InnateDB Gene

IDBG-187936 (Htatip2)

Protein Structure

UniProt Annotation

Function

Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. {ECO:0000269PubMed:14695192}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus envelope {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0030154	cell differentiation
GO:0045765	regulation of angiogenesis
GO:0051170	nuclear import
GO:0055114	oxidation-reduction process