InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr1b

Summary

InnateDB Protein

IDBP-188147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr1b

Protein Name

5-hydroxytryptamine (serotonin) receptor 1B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050898

InnateDB Gene

IDBG-188145 (Htr1b)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269PubMed:10651141, ECO:0000269PubMed:1557407, ECO:0000269PubMed:16750486, ECO:0000269PubMed:8091214, ECO:0000269PubMed:8742487, ECO:0000269PubMed:9349547}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:1557407}; Multi-pass membrane protein {ECO:0000269PubMed:1557407}.

Disease Associations

Tissue Specificity

Predominantly expressed in striatum and Purkinje cells. {ECO:0000269PubMed:1557407}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0008144	drug binding
GO:0051378	serotonin binding

Biological Process

GO:0002031	G-protein coupled receptor internalization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007631	feeding behavior
GO:0014063	negative regulation of serotonin secretion
GO:0035690	cellular response to drug
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0046849	bone remodeling
GO:0050795	regulation of behavior
GO:0071312	cellular response to alkaloid
GO:0071502	cellular response to temperature stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96274

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002147 5-Hydroxytryptamine 1B receptor
IPR002231 5-hydroxytryptamine receptor family
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00513
PR01101
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28334