InnateDB Protein
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IDBP-188150.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cplx1
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Protein Name
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complexin 1
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Synonyms
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921-S;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000038502
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InnateDB Gene
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IDBG-188148 (Cplx1)
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Protein Structure
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Function |
Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. {ECO:0000269PubMed:15126625, ECO:0000269PubMed:16000319}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:15126625, ECO:0000269PubMed:7635198}. Note=Enriched at synaptic-releasing sites in mature neurons.
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Disease Associations |
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Tissue Specificity |
Nervous system, and pancreatic islet cells. Present in many brain regions, including hippocampus and cerebellum. In the retina, present at conventional amacrine cell synapses (at protein level). {ECO:0000269PubMed:15126625, ECO:0000269PubMed:15911881, ECO:0000269PubMed:7635198}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104727
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InterPro |
IPR008849
Synaphin
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PFAM |
PF05835
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63040
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PhosphoSite |
PhosphoSite-P63040
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TrEMBL |
D3YZ72
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UniProt Splice Variant |
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Entrez Gene |
12889
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UniGene |
Mm.5195
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RefSeq |
NP_031782
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MGI ID |
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MGI Symbol |
Cplx1
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OMIM |
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CCDS |
CCDS39206
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HPRD |
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IMGT |
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EMBL |
AC133896
AK134820
AK158166
AK159026
BC014803
D38614
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GenPept |
AAH14803
BAA07605
BAE22299
BAE34390
BAE34774
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