Mus musculus Protein: Gak
Summary
InnateDB Protein IDBP-188162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gak
Protein Name cyclin G associated kinase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036705
InnateDB Gene IDBG-188160 (Gak)
Protein Structure
UniProt Annotation
Function Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0007049 cell cycle
GO:0009913 epidermal cell differentiation
GO:0035622 intrahepatic bile duct development
GO:0048468 cell development
GO:0048853 forebrain morphogenesis
GO:0061436 establishment of skin barrier
GO:0072318 clathrin coat disassembly
GO:0072583 clathrin-mediated endocytosis
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005794 Golgi apparatus
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2442153
InterPro IPR000008 C2 domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001623 DnaJ domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR014020 Tensin phosphatase, C2 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain
PFAM PF00168
PF00069
PF07714
PF00226
PF10409
PRINTS PR00360
PR00109
PR00625
PIRSF
SMART SM00239
SM00271
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99KY4
PhosphoSite PhosphoSite-Q99KY4
TrEMBL Q3UDE5
UniProt Splice Variant
Entrez Gene 231580
UniGene Mm.488147
RefSeq NP_705797
MGI ID
MGI Symbol Gak
OMIM
CCDS CCDS19513
HPRD
IMGT
EMBL AC133896 AC161813 AK034637 AK150112 AK166682 BC003958 BC030859 BC060622 BC065052
GenPept AAH03958 AAH30859 AAH60622 AAH65052 BAC28779 BAE29316 BAE38941