InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Henmt1

Summary

InnateDB Protein

IDBP-188192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Henmt1

Protein Name

RIKEN cDNA 4921515J06 gene

Synonyms

4921515J06Rik; Hen1; mHEN1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054829

InnateDB Gene

IDBG-188190 (Henmt1)

Protein Structure

UniProt Annotation

Function

Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000269PubMed:17652135, ECO:0000269PubMed:18029764}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in testis. {ECO:0000269PubMed:17652135, ECO:0000269PubMed:18029764}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0008171	O-methyltransferase activity
GO:0008173	RNA methyltransferase activity
GO:0046872	metal ion binding