InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pex6

Summary

InnateDB Protein

IDBP-188205.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pex6

Protein Name

peroxisomal biogenesis factor 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002840

InnateDB Gene

IDBG-188203 (Pex6)

Protein Structure

UniProt Annotation

Function

Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Peroxisome membrane. Note=Associated with peroxisomal membranes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0032403	protein complex binding
GO:0042623	ATPase activity, coupled

Biological Process

GO:0006200	ATP catabolic process
GO:0006625	protein targeting to peroxisome
GO:0007031	peroxisome organization
GO:0016561	protein import into peroxisome matrix, translocation
GO:0050821	protein stabilization