InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vav3

Summary

InnateDB Protein

IDBP-188388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vav3

Protein Name

vav 3 oncogene

Synonyms

A530094I06Rik; AA986410; Idd18.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036270

InnateDB Gene

IDBG-188386 (Vav3)

Protein Structure

UniProt Annotation

Function

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion. {ECO:0000250, ECO:0000269PubMed:15711558, ECO:0000269PubMed:16782872, ECO:0000269PubMed:19147786}.

Subcellular Localization

Disease Associations

Tissue Specificity

Abundantly expressed in osteoclasts and mature osteoblasts. Also expressed in bone marrow macrophages (at protein level):.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006906	vesicle fusion
GO:0006974	cellular response to DNA damage stimulus
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0016477	cell migration
GO:0030031	cell projection assembly
GO:0030032	lamellipodium assembly
GO:0030593	neutrophil chemotaxis
GO:0030890	positive regulation of B cell proliferation
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0043087	regulation of GTPase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045785	positive regulation of cell adhesion
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1888518

InterPro

IPR000219 Dbl homology (DH) domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR003096 Smooth muscle protein/calponin
IPR010481 CDC24 calponin
IPR011511 Variant SH3 domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM