Version 5.4
Mus musculus Protein: Slc17a6
Summary
InnateDB Protein IDBP-188423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc17a6
Protein Name solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000032710
InnateDB Gene IDBG-188421 (Slc17a6)
Protein Structure
UniProt Annotation
Function Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269PubMed:11432869, ECO:0000269PubMed:15103023, ECO:0000269PubMed:15118123, ECO:0000269PubMed:17108179}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome.
Disease Associations
Tissue Specificity Expressed in brain. Expressed in hippocampal neurons (at protein level). {ECO:0000269PubMed:11432869, ECO:0000269PubMed:15103023, ECO:0000269PubMed:15118123, ECO:0000269PubMed:16942593}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0001504 neurotransmitter uptake
GO:0006814 sodium ion transport
GO:0015813 L-glutamate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0008021 synaptic vesicle
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0043005 neuron projection
Protein Structure and Domains
PDB ID MGI:2156052
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLE7
PhosphoSite PhosphoSite-Q8BLE7
TrEMBL
UniProt Splice Variant
Entrez Gene 140919
UniGene Mm.256618
RefSeq NP_543129
MGI ID
MGI Symbol Slc17a6
OMIM
CCDS CCDS39969
HPRD
IMGT
EMBL AF324864 AK045409 BC038375
GenPept AAH38375 AAL08941 BAC32349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca