InnateDB Protein
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IDBP-188423.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc17a6
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Protein Name
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solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000032710
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InnateDB Gene
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IDBG-188421 (Slc17a6)
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Protein Structure
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Function |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269PubMed:11432869, ECO:0000269PubMed:15103023, ECO:0000269PubMed:15118123, ECO:0000269PubMed:17108179}.
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Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome.
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Disease Associations |
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Tissue Specificity |
Expressed in brain. Expressed in hippocampal neurons (at protein level). {ECO:0000269PubMed:11432869, ECO:0000269PubMed:15103023, ECO:0000269PubMed:15118123, ECO:0000269PubMed:16942593}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005313
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L-glutamate transmembrane transporter activity
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GO:0015293
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symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2156052
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InterPro |
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BLE7
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PhosphoSite |
PhosphoSite-Q8BLE7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
140919
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UniGene |
Mm.256618
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RefSeq |
NP_543129
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MGI ID |
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MGI Symbol |
Slc17a6
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OMIM |
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CCDS |
CCDS39969
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HPRD |
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IMGT |
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EMBL |
AF324864
AK045409
BC038375
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GenPept |
AAH38375
AAL08941
BAC32349
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