InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFRP1

Summary

InnateDB Protein

IDBP-18870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFRP1

Protein Name

secreted frizzled-related protein 1

Synonyms

FRP; FRP-1; FRP1; FrzA; SARP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000220772

InnateDB Gene

IDBG-18868 (SFRP1)

Protein Structure

UniProt Annotation

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.

Subcellular Localization

Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.

Disease Associations

Tissue Specificity

Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. {ECO:0000269PubMed:9391078}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008201	heparin binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042802	identical protein binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001657	ureteric bud development
GO:0001756	somitogenesis
GO:0001843	neural tube closure
GO:0001944	vasculature development
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006508	proteolysis
GO:0007420	brain development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0009267	cellular response to starvation
GO:0009950	dorsal/ventral axis specification
GO:0009952	anterior/posterior pattern specification
GO:0010564	regulation of cell cycle process
GO:0010629	negative regulation of gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0014034	neural crest cell fate commitment
GO:0014070	response to organic cyclic compound
GO:0021915	neural tube development
GO:0022601	menstrual cycle phase
GO:0030097	hemopoiesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030279	negative regulation of ossification
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030514	negative regulation of BMP signaling pathway
GO:0032855	positive regulation of Rac GTPase activity
GO:0033689	negative regulation of osteoblast proliferation
GO:0035019	somatic stem cell maintenance
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043508	negative regulation of JUN kinase activity
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0044345	stromal-epithelial cell signaling involved in prostate gland development
GO:0045578	negative regulation of B cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045765	regulation of angiogenesis
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046546	development of primary male sexual characteristics
GO:0046676	negative regulation of insulin secretion
GO:0046851	negative regulation of bone remodeling
GO:0048147	negative regulation of fibroblast proliferation
GO:0048546	digestive tract morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060218	hematopoietic stem cell differentiation
GO:0060346	bone trabecula formation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071305	cellular response to vitamin D
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0071380	cellular response to prostaglandin E stimulus
GO:0071391	cellular response to estrogen stimulus
GO:0071392	cellular response to estradiol stimulus
GO:0071456	cellular response to hypoxia
GO:0071481	cellular response to X-ray
GO:0071504	cellular response to heparin
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071773	cellular response to BMP stimulus
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090175	regulation of establishment of planar polarity
GO:0090179	planar cell polarity pathway involved in neural tube closure
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:0090246	convergent extension involved in somitogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052	positive regulation of non-canonical Wnt signaling pathway
GO:2000054	negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:2000080	negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270	negative regulation of fibroblast apoptotic process
GO:2000271	positive regulation of fibroblast apoptotic process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N474