Homo sapiens Protein: SFRP1
InnateDB Protein IDBP-18870.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFRP1
Protein Name secreted frizzled-related protein 1
Synonyms FRP; FRP-1; FRP1; FrzA; SARP2;
Species Homo sapiens
Ensembl Protein ENSP00000220772
InnateDB Gene IDBG-18868 (SFRP1)
Protein Structure
UniProt Annotation
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.
Subcellular Localization Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Disease Associations
Tissue Specificity Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. {ECO:0000269PubMed:9391078}.
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005109 frizzled binding
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008201 heparin binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0042802 identical protein binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0001944 vasculature development
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006508 proteolysis
GO:0007420 brain development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009267 cellular response to starvation
GO:0009950 dorsal/ventral axis specification
GO:0009952 anterior/posterior pattern specification
GO:0010564 regulation of cell cycle process
GO:0010629 negative regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0014034 neural crest cell fate commitment
GO:0014070 response to organic cyclic compound
GO:0021915 neural tube development
GO:0022601 menstrual cycle phase
GO:0030097 hemopoiesis
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0032855 positive regulation of Rac GTPase activity
GO:0033689 negative regulation of osteoblast proliferation
GO:0035019 somatic stem cell maintenance
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043508 negative regulation of JUN kinase activity
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044345 stromal-epithelial cell signaling involved in prostate gland development
GO:0045578 negative regulation of B cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045765 regulation of angiogenesis
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046546 development of primary male sexual characteristics
GO:0046676 negative regulation of insulin secretion
GO:0046851 negative regulation of bone remodeling
GO:0048147 negative regulation of fibroblast proliferation
GO:0048546 digestive tract morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060218 hematopoietic stem cell differentiation
GO:0060346 bone trabecula formation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0071305 cellular response to vitamin D
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071481 cellular response to X-ray
GO:0071504 cellular response to heparin
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071773 cellular response to BMP stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090175 regulation of establishment of planar polarity
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090246 convergent extension involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052 positive regulation of non-canonical Wnt signaling pathway
GO:2000054 negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
GO:2000080 negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
InterPro IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain
PFAM PF01759
Post-translational Modifications
SwissProt Q8N474
PhosphoSite PhosphoSite-Q8N474
UniProt Splice Variant
Entrez Gene 6422
UniGene Hs.213424
RefSeq NP_003003
OMIM 604156
HPRD 09165
EMBL AF001900 AF017987 AF056087 AF229191 AF229192 AK293090 BC036503
GenPept AAB61576 AAB70793 AAC12877 AAH36503 AAK00753 BAF85779