InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Guca1a

Summary

InnateDB Protein

IDBP-189057.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Guca1a

Protein Name

guanylate cyclase activator 1a (retina)

Synonyms

GC-A; Gcap1; Guca1; mGCAP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060027

InnateDB Gene

IDBG-189055 (Guca1a)

Protein Structure

UniProt Annotation

Function

Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Subcellular Localization

Membrane; Lipid-anchor.

Disease Associations

Tissue Specificity

Retina; rod and cone outer segments.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0008048	calcium sensitive guanylate cyclase activator activity
GO:0030249	guanylate cyclase regulator activity

Biological Process

GO:0007165	signal transduction
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0031282	regulation of guanylate cyclase activity
GO:0031284	positive regulation of guanylate cyclase activity

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005578	proteinaceous extracellular matrix
GO:0005886	plasma membrane
GO:0016020	membrane