InnateDB Protein
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IDBP-18907.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TYW1
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Protein Name
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tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354795
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InnateDB Gene
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IDBG-18905 (TYW1)
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Protein Structure
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Function |
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N- methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001094
Flavodoxin
IPR008254
Flavodoxin/nitric oxide synthase
IPR029039
Flavoprotein-like
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PFAM |
PF00258
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PRINTS |
PR00369
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NV66
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PhosphoSite |
PhosphoSite-Q9NV66
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55253
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UniGene |
Hs.653693
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RefSeq |
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HUGO |
HGNC:25598
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OMIM |
611243
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CCDS |
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HPRD |
07711
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IMGT |
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EMBL |
AC006480
AC073089
AC079920
AK001762
AK022917
BC015591
BC042156
BC051888
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GenPept |
AAH15591
AAH42156
AAH51888
AAS07520
AAS07568
BAA91891
BAB14307
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