InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TYW1

Summary

InnateDB Protein

IDBP-18909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYW1

Protein Name

tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352645

InnateDB Gene

IDBG-18905 (TYW1)

Protein Structure

UniProt Annotation

Function

Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N- methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005506	iron ion binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0016829	lyase activity
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding