Version 5.4
Mus musculus Protein: Nipa1
Summary
InnateDB Protein IDBP-189323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nipa1
Protein Name non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000053871
InnateDB Gene IDBG-189321 (Nipa1)
Protein Structure
UniProt Annotation
Function Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+). {ECO:0000269PubMed:17166836}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Early endosome {ECO:0000269PubMed:17166836}. Note=Recruited to the cell membrane in response to low extracellular magnesium.
Disease Associations
Tissue Specificity Widely expressed. Predominantly expressed in neuronal tissues. Brain, heart, kidney, liver and colon (at protein level). {ECO:0000269PubMed:14508708, ECO:0000269PubMed:17166836}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015095 magnesium ion transmembrane transporter activity
Biological Process
GO:0015693 magnesium ion transport
Cellular Component
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2442058
InterPro IPR008521 Magnesium transporter NIPA
PFAM PF05653
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BHK1
PhosphoSite PhosphoSite-
TrEMBL Q3TLT5
UniProt Splice Variant
Entrez Gene 233280
UniGene Mm.389901
RefSeq NP_705806
MGI ID
MGI Symbol Nipa1
OMIM
CCDS CCDS21317
HPRD
IMGT
EMBL AK046619 AK166325 AY098645 BC055828
GenPept AAH55828 AAM34534 BAC32809 BAE38707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca