InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FEM1B

Summary

InnateDB Protein

IDBP-18950.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FEM1B

Protein Name

fem-1 homolog b (C. elegans)

Synonyms

F1A-ALPHA; F1AA; FEM1-beta;

Species

Homo sapiens

Ensembl Protein

ENSP00000307298

InnateDB Gene

IDBG-18948 (FEM1B)

Protein Structure

UniProt Annotation

Function

Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. {ECO:0000269PubMed:10542291, ECO:0000269PubMed:19330022}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19330022}. Nucleus {ECO:0000269PubMed:19330022}. Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment. Associated with chromatin.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in testis. Weakly expressed in other tissues. {ECO:0000269PubMed:10542291}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005123	death receptor binding
GO:0005515	protein binding

Biological Process

GO:0002070	epithelial cell maturation
GO:0006915	apoptotic process
GO:0016567	protein ubiquitination
GO:0051438	regulation of ubiquitin-protein ligase activity
GO:0060442	branching involved in prostate gland morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000001	regulation of DNA damage checkpoint