InnateDB Protein
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IDBP-189512.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ctc1
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Protein Name
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RIKEN cDNA 1500010J02 gene
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Synonyms
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1500010J02Rik; AAF-132; AAF132;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021278
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InnateDB Gene
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IDBG-189510 (Ctc1)
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Protein Structure
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Function |
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. {ECO:0000269PubMed:19854130}.
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Subcellular Localization |
Nucleus. Chromosome, telomere. Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1916214
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5SUQ9
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PhosphoSite |
PhosphoSite-Q5SUQ9
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TrEMBL |
E0CXE7
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UniProt Splice Variant |
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Entrez Gene |
68964
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UniGene |
Mm.285785
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RefSeq |
NP_001268394
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MGI ID |
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MGI Symbol |
Ctc1
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OMIM |
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CCDS |
CCDS48824
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HPRD |
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IMGT |
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EMBL |
AK005190
AK038651
AK044055
AK145919
AK165906
AL645902
BC014687
BC060629
BC147495
BC147497
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GenPept |
AAH14687
AAH60629
AAI47496
AAI47498
BAB23872
BAC30081
BAC31756
BAE26750
BAE38452
CAI24441
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