Version 5.4
Mus musculus Protein: Dlgap3
Summary
InnateDB Protein IDBP-189578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlgap3
Protein Name discs, large (Drosophila) homolog-associated protein 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000039724
InnateDB Gene IDBG-189576 (Dlgap3)
Protein Structure
UniProt Annotation
Function May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15024750}; Peripheral membrane protein {ECO:0000269PubMed:15024750}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:15024750}. Cell junction, synapse {ECO:0000269PubMed:15024750}. Note=Postsynaptic density of neuronal cells.
Disease Associations
Tissue Specificity Highly expressed in central and peripherical nervous system (at protein level). {ECO:0000269PubMed:15024750}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
Biological Process
GO:0007267 cell-cell signaling
Cellular Component
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:3039563
InterPro IPR005026 Guanylate-kinase-associated protein
PFAM PF03359
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PFD5
PhosphoSite PhosphoSite-Q6PFD5
TrEMBL Q3TY61
UniProt Splice Variant
Entrez Gene 242667
UniGene
RefSeq NP_941020
MGI ID
MGI Symbol Dlgap3
OMIM
CCDS CCDS18665
HPRD
IMGT
EMBL AK158868 AY243848 BC057615 BC058433
GenPept AAH57615 AAH58433 AAO89219 BAE34702

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca