Version 5.4
Mus musculus Protein: Zfp90
Summary
InnateDB Protein IDBP-189907.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp90
Protein Name zinc finger protein 90
Synonyms 6430515L01Rik; KRAB17; mKIAA1954; NK10; Zfp64; Zfp83;
Species Mus musculus
Ensembl Protein ENSMUSP00000034382
InnateDB Gene IDBG-189905 (Zfp90)
Protein Structure
UniProt Annotation
Function May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Brain, heart, spleen, thymus, and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043392 negative regulation of DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:104786
InterPro IPR001909 Krueppel-associated box
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF01352
PF00096
PRINTS
PIRSF
SMART SM00349
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61967
PhosphoSite PhosphoSite-Q61967
TrEMBL
UniProt Splice Variant
Entrez Gene 22751
UniGene
RefSeq NP_035894
MGI ID
MGI Symbol Zfp90
OMIM
CCDS CCDS22635
HPRD
IMGT
EMBL AK032286 AK050519 AK154205 BC046298 X79828
GenPept AAH46298 BAC27794 BAC34302 BAE32436 CAA56225

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca