InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phc2

Summary

InnateDB Protein

IDBP-190109.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phc2

Protein Name

polyhomeotic-like 2 (Drosophila)

Synonyms

A3galt2; AA415044; D130050K19Rik; D4Ertd810e; Edr2; Mph2; p36;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030588

InnateDB Gene

IDBG-190107 (Phc2)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269PubMed:16024804}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 2 is ubiquitously expressed in embryos and adult tissues at much higher level than isoform 1. {ECO:0000269PubMed:12034499}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	23 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex

Protein Structure and Domains

PDB ID

MGI:1860454

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR012313 Zinc finger, FCS-type
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QWH1