Version 5.4
Mus musculus Protein: Sass6
Summary
InnateDB Protein IDBP-190156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sass6
Protein Name spindle assembly 6 homolog (C. elegans)
Synonyms 2810453L12Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000029571
InnateDB Gene IDBG-190154 (Sass6)
Protein Structure
UniProt Annotation
Function Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. {ECO:0000269PubMed:24240477}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Note=Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis (By similarity). Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. {ECO:0000250, ECO:0000269PubMed:24240477}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007099 centriole replication
GO:0051298 centrosome duplication
Cellular Component
GO:0005814 centriole
GO:0098536 deuterosome
Protein Structure and Domains
PDB ID MGI:1920026
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80UK7
PhosphoSite PhosphoSite-Q80UK7
TrEMBL
UniProt Splice Variant
Entrez Gene 72776
UniGene Mm.440836
RefSeq NP_082625
MGI ID
MGI Symbol Sass6
OMIM
CCDS CCDS17789
HPRD
IMGT
EMBL AC131038 AK013338 BC050110
GenPept AAH50110 BAB28799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca