InnateDB Protein
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IDBP-190159.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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A3galt2
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Protein Name
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alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030585
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InnateDB Gene
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IDBG-190157 (A3galt2)
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Protein Structure
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Function |
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids. {ECO:0000269PubMed:15539565, ECO:0000269PubMed:16456004}.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Also found in numerous large vesicles throughout the cytoplasm of the soma. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Thymus and lung. {ECO:0000269PubMed:16456004}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0001962
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alpha-1,3-galactosyltransferase activity
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GO:0016757
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transferase activity, transferring glycosyl groups
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0046872
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metal ion binding
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GO:0047276
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N-acetyllactosaminide 3-alpha-galactosyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2685279
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InterPro |
IPR005076
Glycosyl transferase, family 6
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF03414
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3V1N9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
215493
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UniGene |
Mm.300900
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RefSeq |
NP_001009819
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MGI ID |
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MGI Symbol |
A3galt2
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OMIM |
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CCDS |
CCDS18675
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HPRD |
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IMGT |
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EMBL |
AK132334
AL611983
AY491982
CU467499
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GenPept |
AAS66769
BAE21111
CAQ52295
CAQ52296
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