InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fndc5

Summary

InnateDB Protein

IDBP-190513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fndc5

Protein Name

fibronectin type III domain containing 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099660

InnateDB Gene

IDBG-190511 (Fndc5)

Protein Structure

UniProt Annotation

Function

Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. {ECO:0000269PubMed:22237023}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein. Secreted. Note=Imported in peroxisomes through the PEX5 receptor pathway.Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise.

Disease Associations

Tissue Specificity

In adult, it is highly expressed in skeletal muscle, heart and brain. {ECO:0000269PubMed:12112469, ECO:0000269PubMed:12384288}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding

Biological Process

GO:0014850	response to muscle activity
GO:0090336	positive regulation of brown fat cell differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane