InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctsh

Summary

InnateDB Protein

IDBP-190586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctsh

Protein Name

cathepsin H

Synonyms

AL022844;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034915

InnateDB Gene

IDBG-190584 (Ctsh)

Protein Structure

UniProt Annotation

Function

Important for the overall degradation of proteins in lysosomes.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Widely expressed with highest expression found in non-skeletal tissues. Low levels found in skeletal tissue. {ECO:0000269PubMed:10395917}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004177	aminopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016505	peptidase activator activity involved in apoptotic process
GO:0030108	HLA-A specific activating MHC class I receptor activity
GO:0030984	kininogen binding
GO:0032403	protein complex binding
GO:0043621	protein self-association
GO:0070324	thyroid hormone binding

Biological Process

GO:0001656	metanephros development
GO:0001913	T cell mediated cytotoxicity
GO:0002250	adaptive immune response
GO:0002764	immune response-regulating signaling pathway
GO:0006508	proteolysis
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007283	spermatogenesis
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010813	neuropeptide catabolic process
GO:0010815	bradykinin catabolic process
GO:0010952	positive regulation of peptidase activity
GO:0030335	positive regulation of cell migration
GO:0031638	zymogen activation
GO:0031648	protein destabilization
GO:0032526	response to retinoic acid
GO:0033619	membrane protein proteolysis
GO:0043066	negative regulation of apoptotic process
GO:0043129	surfactant homeostasis
GO:0045766	positive regulation of angiogenesis
GO:0060448	dichotomous subdivision of terminal units involved in lung branching
GO:0070371	ERK1 and ERK2 cascade
GO:0097067	cellular response to thyroid hormone stimulus
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0001520	outer dense fiber
GO:0001669	acrosomal vesicle
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0005829	cytosol
GO:0005930	axoneme
GO:0070062	extracellular vesicular exosome
GO:0097208	alveolar lamellar body