InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chrna7

Summary

InnateDB Protein

IDBP-190677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrna7

Protein Name

cholinergic receptor, nicotinic, alpha polypeptide 7

Synonyms

Acra7; alpha7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032738

InnateDB Gene

IDBG-190675 (Chrna7)

Protein Structure

UniProt Annotation

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008179	adenylate cyclase binding
GO:0015464	acetylcholine receptor activity
GO:0015643	toxic substance binding
GO:0017081	chloride channel regulator activity
GO:0019901	protein kinase binding
GO:0042166	acetylcholine binding
GO:0042803	protein homodimerization activity
GO:0051117	ATPase binding
GO:0097110	scaffold protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001666	response to hypoxia
GO:0001988	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0007271	synaptic transmission, cholinergic
GO:0007613	memory
GO:0008284	positive regulation of cell proliferation
GO:0008306	associative learning
GO:0014061	regulation of norepinephrine secretion
GO:0019228	neuronal action potential
GO:0030317	sperm motility
GO:0032094	response to food
GO:0032225	regulation of synaptic transmission, dopaminergic
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0042391	regulation of membrane potential
GO:0042416	dopamine biosynthetic process
GO:0042698	ovulation cycle
GO:0045471	response to ethanol
GO:0045766	positive regulation of angiogenesis
GO:0048149	behavioral response to ethanol
GO:0050727	regulation of inflammatory response
GO:0050728	negative regulation of inflammatory response
GO:0060112	generation of ovulation cycle rhythm

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0009897	external side of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0032279	asymmetric synapse
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:99779

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49582