InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptbp2

Summary

InnateDB Protein

IDBP-190827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptbp2

Protein Name

polypyrimidine tract binding protein 2

Synonyms

brPTB; nPTB; Ptb2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029780

InnateDB Gene

IDBG-190825 (Ptbp2)

Protein Structure

UniProt Annotation

Function

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. {ECO:0000269PubMed:10829067, ECO:0000269PubMed:11726525}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10829067}.

Disease Associations

Tissue Specificity

Mainly expressed in brain, including cerebellum, brainstem, spinal cord, and hypothalamus. Also expressed in the peripheral nervous system and neural crest derivatives, including the dorsal root and trigeminal ganglia, the cochlear spiral and intestinal ganglion cells, and the adrenal medulla. Also detected to a lower extent in testis, heart, liver, lung, skeletal muscle and thymus (at protein level). {ECO:0000269PubMed:10829067, ECO:0000269PubMed:11231079}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006376	mRNA splice site selection
GO:0006397	mRNA processing
GO:0033119	negative regulation of RNA splicing
GO:2000177	regulation of neural precursor cell proliferation