InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASL11A

Summary

InnateDB Protein

IDBP-19093.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASL11A

Protein Name

RAS-like, family 11, member A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000241463

InnateDB Gene

IDBG-19091 (RASL11A)

Protein Structure

UniProt Annotation

Function

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Note=Associates with rDNA transcription unit throughout the cell cycle. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells. {ECO:0000269PubMed:15033445, ECO:0000269PubMed:17628721}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0045943	positive regulation of transcription from RNA polymerase I promoter

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt