Mus musculus Protein: Lgr5 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-190953.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Lgr5 | ||||||||||||||||||
Protein Name | leucine rich repeat containing G protein coupled receptor 5 | ||||||||||||||||||
Synonyms | FEX; Gpr49; | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Protein | ENSMUSP00000020350 | ||||||||||||||||||
InnateDB Gene | IDBG-190951 (Lgr5) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269PubMed:21727895}. | ||||||||||||||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in the gonads, the adrenal gland, and in the brain. In the central nervous system expression is restricted to the olfactory bulb. In the adrenal gland detected only in the neural-crest derived chromaffin cells of the medulla, but not in the cells of the adrenal cortex. In the gonads, the expression is high in Graafian follicle, but absent from primary and secondary follicles. In the intestine, exclusively expressed in cycling crypt base columnar cells. Expressed in the lower bulge and secondary germ area of telogen hair follicles and in the lower outer root sheath of anagen hair follicle. {ECO:0000269PubMed:17934449, ECO:0000269PubMed:18849992, ECO:0000269PubMed:9920770}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | MGI:1341817 | ||||||||||||||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000372 Leucine-rich repeat-containing N-terminal IPR001611 Leucine-rich repeat IPR002131 Glycoprotein hormone receptor family IPR003591 Leucine-rich repeat, typical subtype IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
PF01462 PF00560 PF13504 PF13855 |
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PRINTS |
PR00237
PR00373 |
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PIRSF | |||||||||||||||||||
SMART |
SM00013
SM00369 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9Z1P4 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9Z1P4 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 14160 | ||||||||||||||||||
UniGene | Mm.42103 | ||||||||||||||||||
RefSeq | NP_034325 | ||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | Lgr5 | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS24180 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF110818 AK132387 CH466539 | ||||||||||||||||||
GenPept | AAD14684 BAE21138 EDL21773 | ||||||||||||||||||