InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tulp3

Summary

InnateDB Protein

IDBP-190959.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tulp3

Protein Name

tubby-like protein 3

Synonyms

2310022L06Rik; AI316887;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001562

InnateDB Gene

IDBG-190957 (Tulp3)

Protein Structure

UniProt Annotation

Function

Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. {ECO:0000269PubMed:19286674, ECO:0000269PubMed:19334287}.

Subcellular Localization

Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm. Secreted. Note=Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide- binding protein G(q) subunit alpha (By similarity). Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed including eyes and adipose depots. {ECO:0000269PubMed:9828123}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0032403	protein complex binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001841	neural tube formation
GO:0001843	neural tube closure
GO:0007420	brain development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008589	regulation of smoothened signaling pathway
GO:0009952	anterior/posterior pattern specification
GO:0021904	dorsal/ventral neural tube patterning
GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021915	neural tube development
GO:0021953	central nervous system neuron differentiation
GO:0031076	embryonic camera-type eye development
GO:0042733	embryonic digit morphogenesis
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048702	embryonic neurocranium morphogenesis
GO:0060173	limb development
GO:0060348	bone development
GO:0060434	bronchus morphogenesis
GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061548	ganglion development
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0005930	axoneme
GO:0030991	intraciliary transport particle A
GO:0072372	primary cilium
GO:0097546	ciliary base