Version 5.4
Mus musculus Protein: Tpst2
Summary
InnateDB Protein IDBP-191048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpst2
Protein Name protein-tyrosine sulfotransferase 2
Synonyms AI448750; D5Ucla3; grm; grt; Tango13b;
Species Mus musculus
Ensembl Protein ENSMUSP00000031287
InnateDB Gene IDBG-191044 (Tpst2)
Protein Structure
UniProt Annotation
Function Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation
GO:0007342 fusion of sperm to egg plasma membrane
GO:0060468 prevention of polyspermy
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1309516
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88856
PhosphoSite PhosphoSite-O88856
TrEMBL Q3TQN1
UniProt Splice Variant
Entrez Gene 22022
UniGene Mm.410089
RefSeq NP_033445
MGI ID
MGI Symbol Tpst2
OMIM
CCDS CCDS19538
HPRD
IMGT
EMBL AC123795 AC123848 AF049890 AK036436 AK075672 AK163461 BC003721 CH466529
GenPept AAC36060 AAH03721 BAC29428 BAC35887 BAE37351 EDL19977 EDL19978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca