InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plod2

Summary

InnateDB Protein

IDBP-191240.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plod2

Protein Name

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

Synonyms

D530025C14Rik; LH2; Plod-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068611

InnateDB Gene

IDBG-191238 (Plod2)

Protein Structure

UniProt Annotation

Function

Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.

Subcellular Localization

Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.

Disease Associations

Tissue Specificity

Is highly expressed in the heart, lung, kidney, eye, ovary and placenta. {ECO:0000269PubMed:10429951}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008475	procollagen-lysine 5-dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding