InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndnl2

Summary

InnateDB Protein

IDBP-191263.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndnl2

Protein Name

necdin-like 2

Synonyms

5730494G16Rik; AI642138; BB044375; HCA4; mage-g1; Mageg1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091889

InnateDB Gene

IDBG-191261 (Ndnl2)

Protein Structure

UniProt Annotation

Function

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2s) at the E3:substrate complex (By similarity). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14593116}. Nucleus {ECO:0000269PubMed:14593116}. Chromosome, telomere {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11782285, ECO:0000269PubMed:14593116}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006355	regulation of transcription, DNA-templated
GO:0031398	positive regulation of protein ubiquitination
GO:0040008	regulation of growth