InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRYM

Summary

InnateDB Protein

IDBP-19136.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRYM

Protein Name

crystallin, mu

Synonyms

DFNA40; THBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000219599

InnateDB Gene

IDBG-19134 (CRYM)

Protein Structure

UniProt Annotation

Function

Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. {ECO:0000269PubMed:21332720}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in neural tissue, muscle and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0042562	hormone binding
GO:0042803	protein homodimerization activity
GO:0047127	thiomorpholine-carboxylate dehydrogenase activity
GO:0050661	NADP binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006098	pentose-phosphate shunt
GO:0007605	sensory perception of sound
GO:0042403	thyroid hormone metabolic process
GO:0055114	oxidation-reduction process
GO:0070327	thyroid hormone transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003462 Ornithine cyclodeaminase/mu-crystallin
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF02423
PF03446
PF01488
PF03807

PRINTS

PIRSF

PIRSF001439

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14894