InnateDB Protein
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IDBP-191445.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cd68
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Protein Name
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CD68 antigen
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Synonyms
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gp110; Lamp4; Scard1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000018918
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InnateDB Gene
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IDBG-191443 (Cd68)
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Protein Structure
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Function |
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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Subcellular Localization |
Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.Isoform Short: Cell membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in tissue macrophages and to a lesser extent in dendritic cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:88342
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InterPro |
IPR002000
Lysosome-associated membrane glycoprotein
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PFAM |
PF01299
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PRINTS |
PR00336
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P31996
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PhosphoSite |
PhosphoSite-P31996
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12514
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UniGene |
Mm.15819
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RefSeq |
NP_001277987
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MGI ID |
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MGI Symbol |
Cd68
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OMIM |
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CCDS |
CCDS70216
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HPRD |
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IMGT |
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EMBL |
AB009287
AF022651
AF039399
AF045554
AK002264
AK170443
AL603707
BC021637
DQ167574
X68273
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GenPept |
AAC15685
AAC40056
AAC40151
AAH21637
ABA02181
BAA23738
BAB21975
BAE41801
CAA48334
CAI51942
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