InnateDB Protein
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IDBP-191476.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atxn1l
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Protein Name
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ataxin 1-like
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Synonyms
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AW558552; Boat; C330011L24Rik; D6Mgi37; D8Ertd587e; ENSMUSG00000069895;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000090850
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InnateDB Gene
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IDBG-191474 (Atxn1l)
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Protein Structure
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Function |
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1). {ECO:0000250, ECO:0000269PubMed:16121196}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16121196}. Cell projection, dendrite {ECO:0000269PubMed:16121196}. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
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Disease Associations |
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Tissue Specificity |
Expressed in neuronal cells. Highly expressed in Purkinje cells of cerebellum. {ECO:0000269PubMed:16121196}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
59 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3694797
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InterPro |
IPR003652
Ataxin, AXH domain
IPR013723
Ataxin-1/HBP1 module (AXH)
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PFAM |
PF08517
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PRINTS |
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PIRSF |
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SMART |
SM00536
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TIGRFAMs |
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Modification |
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SwissProt |
P0C7T6
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PhosphoSite |
PhosphoSite-P0C7T6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
52335
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UniGene |
Mm.481747
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RefSeq |
NP_001074399
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MGI ID |
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MGI Symbol |
Atxn1l
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OMIM |
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CCDS |
CCDS40474
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HPRD |
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IMGT |
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EMBL |
AC132138
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GenPept |
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