Version 5.4
Mus musculus Protein: Atxn1l
Summary
InnateDB Protein IDBP-191476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atxn1l
Protein Name ataxin 1-like
Synonyms AW558552; Boat; C330011L24Rik; D6Mgi37; D8Ertd587e; ENSMUSG00000069895;
Species Mus musculus
Ensembl Protein ENSMUSP00000090850
InnateDB Gene IDBG-191474 (Atxn1l)
Protein Structure
UniProt Annotation
Function Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1). {ECO:0000250, ECO:0000269PubMed:16121196}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16121196}. Cell projection, dendrite {ECO:0000269PubMed:16121196}. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
Disease Associations
Tissue Specificity Expressed in neuronal cells. Highly expressed in Purkinje cells of cerebellum. {ECO:0000269PubMed:16121196}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0030425 dendrite
Protein Structure and Domains
PDB ID MGI:3694797
InterPro IPR003652 Ataxin, AXH domain
IPR013723 Ataxin-1/HBP1 module (AXH)
PFAM PF08517
PRINTS
PIRSF
SMART SM00536
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0C7T6
PhosphoSite PhosphoSite-P0C7T6
TrEMBL
UniProt Splice Variant
Entrez Gene 52335
UniGene Mm.481747
RefSeq NP_001074399
MGI ID
MGI Symbol Atxn1l
OMIM
CCDS CCDS40474
HPRD
IMGT
EMBL AC132138
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca