Version 5.4
| Mus musculus Protein: Phlpp2 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-191555.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Phlpp2 | ||||||||||
| Protein Name | PH domain and leucine rich repeat protein phosphatase 2 | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000034175 | ||||||||||
| InnateDB Gene | IDBG-191553 (Phlpp2) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Cytoplasm. Membrane; Peripheral membrane protein. Nucleus {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:2444928 | ||||||||||
| InterPro |
IPR001611
Leucine-rich repeat IPR001932 Protein phosphatase 2C (PP2C)-like domain IPR003591 Leucine-rich repeat, typical subtype |
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| PFAM |
PF00560
PF13504 PF13855 PF00481 PF07228 |
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART |
SM00331
SM00332 SM00369 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q8BXA7 | ||||||||||
| PhosphoSite | PhosphoSite-Q8BXA7 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 244650 | ||||||||||
| UniGene | Mm.23494 | ||||||||||
| RefSeq | |||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Phlpp2 | ||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AC122807 AK048260 AK048472 BC117961 BC117962 | ||||||||||
| GenPept | AAI17962 AAI17963 BAC33288 BAC33347 | ||||||||||