InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfsf13

Summary

InnateDB Protein

IDBP-191674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfsf13

Protein Name

tumor necrosis factor (ligand) superfamily, member 13

Synonyms

2310026N09Rik; April; Tall2; Trdl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018896

InnateDB Gene

IDBG-488114 (Tnfsf13)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {ECO:0000269PubMed:15488762}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0002426	immunoglobulin production in mucosal tissue
GO:0002636	positive regulation of germinal center formation
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0016064	immunoglobulin mediated immune response
GO:0048298	positive regulation of isotype switching to IgA isotypes
GO:0050776	regulation of immune response