InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cmklr1

Summary

InnateDB Protein

IDBP-191762.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cmklr1

Protein Name

chemokine-like receptor 1

Synonyms

ChemR23; DEZ; Gpcr27; mcmklr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036316

InnateDB Gene

IDBG-191760 (Cmklr1)

Protein Structure

UniProt Annotation

Function

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B (By similarity). Positively regulates adipogenesis and adipocyte metabolism. {ECO:0000250, ECO:0000269PubMed:15753205, ECO:0000269PubMed:16863918, ECO:0000269PubMed:17635925}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16863918}; Multi-pass membrane protein {ECO:0000269PubMed:16863918}.

Disease Associations

Tissue Specificity

Expressed in the differentiated adipocytes (at protein level). Ubiquitous. Highly expressed in adipose tissue and immature plasmacytoid dendritic cells (DCs) and at lower levels in myeloid DCs, macrophages, and NK cells. Expressed on macrophages isolated from different tissues, including peritoneal cavities, pleural cavities and spleen. {ECO:0000269PubMed:16863918, ECO:0000269PubMed:17635925, ECO:0000269PubMed:17767914, ECO:0000269PubMed:18242188, ECO:0000269PubMed:19841182}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010759	positive regulation of macrophage chemotaxis
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032695	negative regulation of interleukin-12 production
GO:0045600	positive regulation of fat cell differentiation
GO:0050848	regulation of calcium-mediated signaling
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:109603

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002234 Anaphylatoxin chemotactic receptor family
IPR002258 DEZ orphan receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00241
PR00237
PR01104
PR01126

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97468